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Understanding how proteins behave inside living cells is essential for modern drug discovery. Yet many widely used approaches, particularly plasmid overexpression systems and primary antibody–dependent assays, can alter or obscure the biology researchers aim to understand. Overexpression may push proteins above physiologically relevant levels, causing incorrect localization or artificial interactions. Antibody-driven detection strategies vary in…

by Michael Irving, Xylem In pharmaceutical and biopharmaceutical manufacturing, there is zero margin for error when it comes to process integrity and operator safety. Among the many variables that must be tightly controlled, pressure ranks high on the list. Overpressure or vacuum conditions can compromise not only equipment, but also batch sterility, production timelines, and…

By Kimberly Salgado, ICON plc Advancements in biologic therapies have greatly improved our ability to treat cancer over the last few decades — but are typically very costly. With patent expirations encompassing numerous notable oncology biologics, opportunities for oncology biosimilar development are abundant. Biosimilars, less expensive treatments made to closely emulate biologics with expired patents,…

Sponsored by Infor.   Data management in life sciences is inherently complex. Data is fragmented across multiple systems — such as clinical trials, lab systems, regulatory databases, and electronic health records (EHRs) — in inconsistent formats. For example, patient information in the EHR is typically transferred using legacy technology. Additional data streams from wearable devices,…

 This case study is sponsored by Infor. Artificial intelligence can revolutionize clinical interoperability by building bridges across data silos. Machine learning’s vast analytical capabilities enable the comprehensive analysis of large volumes of historical data from multiple sources, providing a more holistic view of patients’ overall health. Its ability to uncover patterns and anticipate future needs…

This case study is sponsored by Infor.  In the complex landscape of clinical trials and medical research, data fragmentation remains a major obstacle, hindering progress and patient outcomes. The case study “Advancing Clinical Trials and Research with Cloverleaf” showcases how Infor Cloverleaf significantly enhances clinical trials by integrating Real-World Evidence (RWE) to overcome data fragmentation.…

By Dr Bryce G Rutter, Head Noble Consulting Services Evaluating device usability throughout the product development process is crucial. A sleek design means little if users struggle to use it effectively. This article explores five key questions for planning global usability tests and the benefits of partnering with experts. 1. What is the Right Sampling…

By Dr. Bryce G Rutter, Head of Consulting Services Arthritis changes how people grasp and manipulate an object, reducing the functional capacity of many adults worldwide; it is one of the most significant considerations when designing combination devices. Ergonomic Combination Devices for Arthritis Patients Arthritis significantly impacts how people grasp and manipulate objects, reducing their…

The U.S. FDA released a final rule to regulate laboratory developed tests (LDTs) on May 6, 2024, making it clear that such tests are classified as in vitro diagnostics (IVDs) and are subject to oversight by the agency. The phaseout of its general enforcement discretion approach for LDTs will happen in stages over a four-year…

The baculovirus–insect cell expression system—insect cells used in conjunction with the baculovirus expression vector system (BEVS)—remains a crucial technology for manufacturing large and complex proteins. This eukaryotic expression system offers inherent safety, ease of scale-up, flexible product design, and versatility for a broad range of proteins. As artificial intelligence and computational technologies advance, aiding in…

Noble International is working with Pharma and Specialty Pharmacy to fix the problem. The report, “The Current Paradigm for Biologic Initiation: A Mixed-Methods Exploration of Practices, Unmet Needs, and Innovation Opportunities in Self-Injection Training,” chronicles a study meant to examine the current injection initiation experiences of patients. Here, significant gaps in training and support were…

By Tim McLeroy, Executive Director of Marketing and Patient Services, Noble International At Noble, the patient journey drives everything we do. Our patient-centered approach pushes us to fully understand and characterize patient needs, providing data and experiences that help us ease the burden and anxiety of self-administered treatments. While drug delivery devices are well designed…

By Cheryl Reifsnyder, PhD As a leading provider of data and advanced analytics, Veradigm understands the critical role real-world data (RWD) play in supporting researchers and other healthcare stakeholders during public health crises such as the unprecedented COVID-19 pandemic. The Value of EHR Data EHR Data: Both Timely and Clinically Rich For studying COVID-19, EHR…

Introduction Since the approval of Orthoclone OKT3 in 1986, more than 100 monoclonal antibodies (mAbs) have been approved by the Food and Drug Administration (FDA) to treat a variety of diseases ranging from autoimmune disorders, infectious diseases, and cancer [1-2]. In the context of the current COVID-19 pandemic, it’s crucial that these biologics are developed…

Losing university access doesn’t mean losing access to articles anymore By DeepDyve Digital Library Team Many researchers are surprised to find that leaving university also means leaving behind something they didn’t expect—easy access to peer-reviewed literature. Especially for those who have gone to work at startups or other smaller organizations, finding a way to do…

By Jan Barghaan, Strategic Marketing Manager Life Science, Olympus Europa No, not fireworks — it’s actually a single colony of Gloeotrichia. While this is an extreme example, can you really trust your images? The answer may depend on your objectives. Objectives are arguably the most important microscope components; you could even think of them as…

By Joanna Hawryluk, PhD, Product Manager, Olympus Life Science Since the early 20th century, cell culture has been considered the gold standard in various research, drug development, and diagnostic labs. Within drug discovery, cell cultures are used to develop and test compounds to determine compound efficiency and efficacy. Before you begin growing cell cultures, you…

By Trevor Smith, MS MBA, Product Manager, Immune Cells Human AB Serum is a staple in the biological research field, providing nutrients, vitamins and necessary growth factors in cellular culture and reliable controls in in vitro diagnostics. To truly understand serum, it is important to learn about its different production and processing methods. Starting material…

With a better understanding of the causes and mechanisms behind diseases arises a need for new treatment options and drugs to address them. However, since drug development is a lengthy and costly process with high attrition rates, the efficacies of potential drugs need to be determined as accurately and efficiently as possible. An important factor…

Human Factors + (HF+) is a natural extension of Noble’s deep understanding of the patient experience relative to self-administering drug therapies By Tim McLeroy, Executive Director of Marketing & Patient Services The global market for medical devices is approximately $436 billion, bolstered by an aging population, according to data from hfMEDIC, the University of Utah-led […]

Researchers in China have used Projection Micro Stereolithography (PµSL) to improve the fabrication of micropillar array electrodes (µAEs) for the identification and detection of biomarkers. PµSL, a micro-precision 3D printing technology from Boston Micro Fabrication (BMF), enabled researchers to produce 3D printed molds for reduced fabrication costs and increased device sensitivity. Most µAEs are fabricated…